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Video abstract of review paper "8-Hydroxyquinolines: a review of its metal chelating properties and medicinal applications" published in the open access journal Drug Design, Development and Therapy by authors Prachayasittikul V, Prachayasittikul S, Ruchirawat S and Prachayasittikul V. Abstract: Metal ions play an important role in biological processes and in metal homeostasis. Metal imbalance is the leading cause for many neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 8-Hydroxyquinoline (8HQ) is a small planar molecule with a lipophilic effect and a metal chelating ability. As a result, 8HQ and its derivatives hold medicinal properties such as antineurodegenerative, anticancer, antioxidant, antimicrobial, anti-inflammatory, and antidiabetic activities. Herein, diverse bioactivities of 8HQ and newly synthesized 8HQ-based compounds are discussed together with their mechanisms of actions and structure-activity relationships. Read the review paper here: http://www.dovepress.com/8-hydroxyquinolines-a-review-of-their-metal-chelating-properties-and-m-peer-reviewed-article-DDDT