0:00:04my name is the mind that i'm the global medical director in immunology it back
0:00:08suppliers lines in ways they reach california
0:00:13the thought the large that the is saved tolerable the key element intravenously administered l
0:00:19one protein a scene with a one i it increased information right
0:00:25and while the randomised placebo mask information rate can fold cross overs that the adults
0:00:36really needs inhibitor
0:00:38also called
0:00:39however one entire strips n
0:00:42a by pi single life prosody and synthesize in the leverage
0:00:46it's font in protective concentration in the lasso healthy individuals
0:00:52in the absence of a one pi
0:00:55there is that damage to the our builder wall which make calls and also marked
0:01:00and thus
0:01:01locked issue and which we maximally to progress in f c
0:01:07currently there are for a bumpy i preparations be very efficient durations from fifty to
0:01:14seventy five minutes
0:01:16it brought by the u s four diagram it is relation
0:01:22infusion duration veriest based on the product save a pi concentration a if you fusion
0:01:28rates
0:01:32glass is
0:01:34the only a rated use liquid preparation of roof i a one pi
0:01:41it is indicate it for twenty or lactation maintenance therapy even adults with clinically evidence
0:01:48that c moderate to severe quite unit to live on the i coefficients
0:01:53i recently in the low commodity infusion rate was zero point zero four will only
0:01:59to or cagey permanent
0:02:03this
0:02:03that the assess the safety until they're able to a glass
0:02:08it in increasing tuition rate of zero what you to and i'll a key cheap
0:02:14per minute within a move shortening the fusion duration
0:02:21it was a prospective randomised rate control the simple mass crossovers studying how subjects
0:02:28last year was eight minutes that a direct command that those of sixty milligrams per
0:02:33k g
0:02:34and human five percent was the others that simplicity but the same way but you
0:02:40patient volume
0:02:42the information rate though they are pi solution was masked by infusing give the simplest
0:02:48solution simultaneously the opposite the inflation rate
0:02:52therefore need that the subjects not a canonical is that for it where we did
0:02:57last year was be i mean is there a direct but or standard completion rate
0:03:04this kind of ten shows the information eight ministrations
0:03:08a by i glass and a placebo were administered simultaneous central y can a their
0:03:16into a single the patient's act
0:03:21the subjects were randomized into two groups
0:03:24it a bond through one receive a by pi it's an increase the inclusion rate
0:03:31weights
0:03:32so let's see well it is standard trait
0:03:36and
0:03:37two received a about i it is standard trait with the placebo containing three is
0:03:43insufficient right
0:03:46graphs were switched all words it a fifty
0:03:50there was a six follow-up want the twin in the high not they
0:03:54hundred and five
0:03:56the subjects were randomized subject demographics are characteristics in group one and go to two
0:04:03more similar
0:04:08looking at worst of and profile
0:04:12were not subjects is continue to study you to adverse impacts
0:04:17all sorta subjects completed boarding features of a bar the c but you to separate
0:04:24treatment periods
0:04:26but not serious course you're rate e is
0:04:30for that
0:04:31it will not talk to six adverse vast were reported to sixteen subjects and all
0:04:37a used reported were all while utterance
0:04:43a more simple and i were survives in six subjects procuring during goal within seventy
0:04:50two hours of the inferior shown and they were considered related to treatment
0:04:56is that of course the mass for this in a slightly she's discomfort fatigue being
0:05:01an extra five now cured it is standard deviation rate at tool that it did
0:05:08a higher completion rate
0:05:12overall the number of the fusion is with the ease that down dream the fusion
0:05:17or we didn't one twenty four or seventy two hours
0:05:21exactly so causality
0:05:24what is known for okay
0:05:26hi unit-fusion rate cool here we this standard deviation rate of a by pi
0:05:36but not in features interrupted or discontinue not knowing features for eight minutes that are
0:05:41produced rate to eight years
0:05:45infusion duration was shortened by a bomb i was a minister data i really efficient
0:05:51rate
0:05:53the infusion duration range from six to four to seven the six minutes with the
0:06:00standard diffusion rate whereas
0:06:03with higher inflation rate the range varied from twelve to fifteen minutes
0:06:11therefore
0:06:12we can conclude that a one i was well tolerated when eight minister that the
0:06:18higher the fusion rate of zero waiting to ability to for key cheaper than it
0:06:24without an increase in the rate of treatment the margin at first glance
0:06:29the increase inflation rate from zero point zero four to zero point to be the
0:06:35leader for key cheaper minutes resulted in a five for shorter you fusion duration
0:06:41we believe that this shortening fusion duration along with their related to use formulation is
0:06:48that but i'm still to improve the quality of life of patience would need to
0:06:52be on at one p i terror you on a weekly basis
0:06:57i q