| 0:00:01 | group members of your answer with only about three hundred patients diagnosed each year states |
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| 0:00:07 | unlike most malignant tumours corpsman is a slow growing locally aggressive and it uses two |
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| 0:00:13 | the current standard actually for court of certainty however its location along critical anatomical structures |
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| 0:00:19 | makes clear to manage difficult undercurrents is a common invented patients with the median survival |
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| 0:00:24 | approximately six years |
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| 0:00:27 | there are few options record them are limited due to the tumours lack of sensitivity |
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| 0:00:31 | to both female and radiotherapy |
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| 0:00:34 | therefore not their strategies are needed to improve the overall survival court patients |
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| 0:00:41 | currently corpus can only be defined by just logic and we used a chemical criteria |
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| 0:00:47 | very little is known about the molecular mechanisms the drug court on the development and |
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| 0:00:51 | they're not predictive or probabilistic markers recorded |
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| 0:00:55 | in this review we summarize the most recent findings in the field of cordon original |
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| 0:01:00 | mix an aboriginal x |
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| 0:01:02 | from comparative genomic hybridization i'm fluorescent in situ hybridisation which exact colours alterations |
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| 0:01:09 | large-scale the any sequencing to find you stations |
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| 0:01:13 | marker is to quantify a morning and micro are expression and you name activation profile |
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| 0:01:20 | he said let significant discoveries towards the biological pathogens this quarter in may potentially overall |
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| 0:01:26 | for molecular their treatment of quarter notes |
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| 0:01:30 | high resolution screening of genetic instabilities by c g h fish provided a more comprehensive |
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| 0:01:36 | landscape of core damage in a courtroom genesis |
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| 0:01:40 | these studies have uncovered not look at it a good genes that are frequently gain |
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| 0:01:44 | in court and not tumour suppressor genes that are lost |
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| 0:01:48 | large-scale da ne sequencing allows us to identify occurring single nucleotides polymorphism is also not |
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| 0:01:55 | snaps then maybe involved in gene just regulation and the development cordon |
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| 0:02:02 | microarray analysis and martin a microarray expression highlights the significant differences expression levels between chord |
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| 0:02:09 | tissues and silence |
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| 0:02:11 | and normal controls |
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| 0:02:13 | do you name appellation profiling reveals the older at any relation patterns that result in |
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| 0:02:18 | genetic instability or just regulated gene expression thus contributing to read genesis and malignant transformation |
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| 0:02:25 | in order |
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| 0:02:27 | these significant advances in identifying what you wish signatures cordon enable us to identify underlying |
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| 0:02:34 | to read genesis mechanism |
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| 0:02:36 | such as cell growth proliferation apart sources and drug resistant smacking |
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| 0:02:42 | it is clear that only exists between agreement development and these genetic averaging operations including |
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| 0:02:48 | chromosome arrangements |
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| 0:02:50 | the annotation activation and mr and my are expression |
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| 0:02:56 | in recent years interest in court dominance-from dramatically and their been important discoveries encoder biology |
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| 0:03:02 | which further work is needed to understand causes molecular bases and rolls these you know |
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| 0:03:07 | make a genetic instabilities tumour cells |
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| 0:03:11 | these integrated approaches may also provide opportunity to identify diagnostic probabilistic workers they can be |
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| 0:03:18 | applied towards personalisation of cancer therapy and significantly improve cargo mechanical turk |
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