hello my name is my case some tiny and on the order of the article
titled disease progression with cd nist in mc i any subjects
the choice of the c d n s one or disease progression analysis in a
patient population close to the answer to dimension
was guided by addison can be addressed guidance undoubtedly grows or the outsiders disease
the draft guidance of course the concept and ridge in clinical trials
the patient's most likely to progress to moreover dementia using what clinical and but are
basic idea
interestingly what patients with this
the draft guidance kinds of std lsp as an example of or was a disease
progression
and as a candidate for a single whatever the efficacy n y
that combines assessment of all mission and function
this is production has coming to describe using linear exponential and logistic structure models in
the literature
in this analysis we formally compared to structure models
the three bottom adjusting model describes an and shape disease progression curve and follows a
nonlinear and such a verbal trajectory that stays within the boundaries of the scale
this analysis indicated that the three but i'm logistic model best describes your data
a problem can be what's is a very but also the regression israel or at
low and high c d n is these scores with human scores of about and
exhibiting faster rates are duration
this involvement use you have relationship is a cat interest a okay and ship progression
curve described by the t parameter logistic model which is also highlighted here
the model predicts that the production rate approaches you don't as the scores of course
the boundaries of the scale
within the range of the scale the production rate is proportional to the current seriously
score one parameter that i just e subject compression rate
and advantage of the lsp is that less and two percent of the observation reside
on the boundaries of the scale for this population and most of the zero one
observations will present the subject that we're by the market negative
moreover a comparison of models with different probability distributions suggested that the larger normal distribution
capture the behavior but assume error appropriately
this is a letter model has the advantage of the model predictions even after accounting
but as to error stay within the boundaries of the scan
a mixture model was to the baseline by marker data
and i shows the density goes based on the mixture model with the estimated threshold
of zero point one or seven what we are living tissue
you don't densities and i don't be sure that cognitively normal and in beaumont the
distributions are quite a state with low and high recalibrated issues respectively
in contrast the and then see i subjects represent a mixture some of the methodology
and some in l
the of the baseline by the mother data on me has regression because it ellen's
i and my e d is shown by l c and d
subjects the baseline be immediate initial below the zero point one four seven to ensure
exhibit a scroll data collection was as those subjects about the first four we show
how much faster progression
equal syllable models that you improvement in more performance
additional task using a bimodal analysis
the first this study assumption
whether the progresses
which to ration represented not regressors this as often was found to be true
this suggests that the csi biomarkers distinguish progressive still not regressors
secondly it was found the best error or not progresses was greater than their vocal
service
this suggests that study nancy i subjects
i do not biomarkers has the potential to reduce errors in a remote controls
additional covariate analysis indicated that episodic memory as measured by the national remember a skin
related logical memory to an executive functioning well also was also you have a regression
the results also suggest that a prosodic boundary is
more predictable progression in latency identity or that it was obvious to be true what
exactly functioning
as part of our analysis it was found that can be does and will have
lower scores as compared to that one complete study
this was done for by the rubber model which suggested that the likelihood of subjects
database missing was related to this score right really about probably now
this was really project was part of the model classification
the rows represent latency i subjects
while the bottom panels
sure my at subjects
because of the lab
after subjects that of a marker negative
where the graph on the right
or something that i by one
the b c suggest that the model described stimulus progression reasoning about in both in
the and they then cfs subjects and by market positive and negative subgroups
in summary csi biomarkers have the ability to discriminate subjects in the progress snr regressors
and that was either one and reading m c i clinical trials
this means of presentation and we hope that you will find out analysis useful