0:00:00the present you data for the treatment of the rack out this function and give
0:00:05an overview of this article
0:00:08you're right account this function is often perceived by locations and sexual partners as a
0:00:14serious problem that can jeopardise quality of life
0:00:18psychosocial
0:00:19or emotional will be
0:00:21and the partnership in the long term
0:00:25although many treatment modalities have been introduced to address it
0:00:29the end of pde five inhibitors have revolutionised the medical treatment for e d which
0:00:36offer advantages over other treatment modalities in terms of use of administration and costs
0:00:43to date there are four pde five inhibitors
0:00:47so but also
0:00:49fire data fell how to fill and a part of the l approved for the
0:00:54treatment of direct of this function well why
0:00:57and you've done to fill has been approved thirteen countries
0:01:01including career
0:01:04in this review
0:01:05we highlight the evidences for the efficacy and safety you gender fill in the treatment
0:01:11of d
0:01:15you don't have l one of selective pde five inhibitors was developed in korea and
0:01:20approved for the treatment of needy in two thousand and five
0:01:25it's far marco kinetic profiles included t max of zero point eight to one point
0:01:31three hours
0:01:33and see how
0:01:34that's nine point nine to twelve point one hours
0:01:38which could convert clinical properties of both relative rapid onset and long duration of ash
0:01:47compared with the syllable
0:01:48you jennifer significantly improves the direct i'll function domain scores of i
0:01:56the rates of successful penetration and maintenance of ration in and with the d but
0:02:02broad spectrum of you q all the keys
0:02:05forces there
0:02:07also you dental treatment showed greater increases in positive responses to the global assessment question
0:02:14compared to placebo
0:02:19also you gender phyllis save effective and well tolerated for the treatment of e d
0:02:25in men with underlying hypertension who take an entire hyper tense address
0:02:33there is evidence that you gotta fill can be as effective in the treatment of
0:02:38diabetes melody is associated e d as other pde five inhibitors
0:02:45due to the clinical properties you jennifer can be another option of deal with those
0:02:50in for the treatment of d as suggested by favourable efficacy and safety profile
0:02:58cover administration of one hundred milligram you'd n f l and out for one blockers
0:03:03improve dirac function and lower urinary tract symptoms impatience with both bp h and e
0:03:11d
0:03:12also the common commitment use of our focus on bloggers does not significantly affect the
0:03:19c d profile of you jennifer
0:03:23most adverse effect reporter by clinical trials are mild or moderate in so there without
0:03:30any serious adverse event with had a and flashing being the most common
0:03:38to date there have been no data on long-term efficacy and holler ability you'd n
0:03:43f l for the treatment you d
0:03:46also there has to sparse data on efficacy and safety you data feel for the
0:03:51treatment of e d in other ethnic populations and east asian population
0:03:58that's research on e d treatment using you don't know that is still ongoing
0:04:05in conclusion you data that has fruit and have high efficacy of favourable safety profile
0:04:10for the broad spectrum you d patients which are compared to those other pde five
0:04:17inhibitors
0:04:18due to the clinical properties of relatively rapid onset and long duration of action you'd
0:04:25and the main be a better option for d treatment according to patient specific sexual
0:04:31and harass
0:04:33you don't have l is as effective in the treatment of diaries mallets is associated
0:04:39e d as a pde five and hitters
0:04:44further studies are still required to validate the efficacy and safety you jennifer
0:04:49and to complement the scientific basis rationale evidence this prescription and dosing decision
0:04:56thank you for your attention