0:00:00my name is not the case you wanna proposed crabtree university of the unit that's
0:00:05kind of
0:00:06on my probably able to just in milan and i used to share with you
0:00:12the findings of our review on addressing the needs of patients with assistant negative symptoms
0:00:17of schizophrenia emerging formal treatment options
0:00:22negative symptoms represent an impediment normal human motor responses for processes is
0:00:30typically the symptoms such as i two one single flattening
0:00:35and he don't near a sociology
0:00:40and a motivational
0:00:43sometimes a problem and it's estimated that up to sixty percent of operations will demonstrate
0:00:48negative symptoms at any point in time
0:00:52however assistant and primary negative symptoms are estimated to look at about twenty five percent
0:00:58of patients schizophrenia
0:01:00maybe assumptions are associated with decreased want to point
0:01:04increased functional disability increase of illness for a comparable
0:01:09unfortunately negative symptoms responsible treatment there are limited rate options no accepted standard okay
0:01:17this may be related to the competitor quality of negative symptoms the which will not
0:01:23only on the aspects of the hypothesis on depending on the sentence but also just
0:01:29function distance or got and lose my whole weights
0:01:34no assumptions were also difficult to assess there are known for all you scales the
0:01:39to be able to take into account patients in experience as well as aspects of
0:01:43motivation
0:01:46the review a randomised control studies that examine specifically patients with no problems in the
0:01:52system negative symptoms
0:01:55maybe this study some included a one very populations use different scales that's it's
0:02:01difficult to evaluate the results are given the potential compounds
0:02:08most existing treatments today have inflated i the second generation cycle six what we use
0:02:14of antidepressants in i don't are you this quite extensive literature concerning both of these
0:02:21in terms of treatment options their number of different well as agents that the actively
0:02:27researched using the unity a perceptual function and also is a agent sagisaka seen or
0:02:33legalising reality inhibitors adjustment of thirteen
0:02:37then we have a possible method but rotate a search perceptron active ages including the
0:02:44and two agents
0:02:46the that any as colour coding receptor antagonist represents a very impulsive agents and that's
0:02:53all i don't therapies
0:02:55finally we have a radio stations from a number of different classes in the cycle
0:03:00stimulants and style assisting euros the overall it's and five h t three receptor antagonist
0:03:09many studies with these agents are relatively small scale open label and the lower and
0:03:15less controlled trials on forty not readily taken some of the findings for the earlier
0:03:20studies
0:03:22in the future the only need
0:03:25patients with the system negative symptoms of schizophrenia is unequivocal
0:03:30because of the context neurobiology underpins negative symptoms progress has actually been quite limited
0:03:38evaluations that we have for some positive data for it is difficult to know what
0:03:43role there will be ip on the right agents or they are trying to three
0:03:49months we used a year later in the course of the owners
0:03:55the remaining questions in terms of the effective bit-rate negative symptoms or redistribute provides a
0:04:00useful clinical summary of the data today more polite conditions in terms of the car
0:04:05choices available to