0:00:04we found that the plane has two different functional state one state as one be
0:00:10awake and that we have our surroundings and another state is one v asleep the
0:00:14difference being that when we have weak the plane sensor working they had processing all
0:00:20the information about our surroundings whereas the during sleep
0:00:24we work very they had all of a moving all the way step in open
0:00:29be a week the or sleep about eight hours every t and b or wonder
0:00:33why do we need to do it even the old greek philosophers wondered why do
0:00:37we need to sleep
0:00:39and if you look at animals you'd find that even words and mice sleep for
0:00:44a long time if we d
0:00:46so that suggests that sleep has of a basic function and its needed if you
0:00:50keep and ml a week that would eventually die
0:00:53some ice would die if you keep them a week for several weeks that would
0:00:57eventually die and be when you don't know why
0:01:00so
0:01:00but until such a perception of
0:01:03basic biological function and our study i believe people pointed by showing yes sleep there
0:01:10is absolutely essential for the movement of talk sequential portal from day to pine they
0:01:15can emphatic system function very much like the garbage removal and then space "'cause" a
0:01:20function of the emphatic system so that works
0:01:24a subset you be had in flocks of simple spinal fluid and on the ad
0:01:29tree getting into the queen that fluid this compared to the brain in between the
0:01:35plate plane so what eight neutral if you are shows toxic waste product we
0:01:41the dirty fluid correlate of around the means
0:01:44and we'll after it is dumps into the no phase and
0:01:48be delivered to the new of a that is how big we cycle obtained when
0:01:52a protein likely to "'em" annoyed another toxic which model can be equated and recycled
0:01:59we infuse the floor rise and the time into the serial bro spinal fluid which
0:02:04we can see as f so from this technique we can see the cs f
0:02:10flow through into the bright in the sleeping mice we found that the csi of
0:02:16flushing to the brain
0:02:17where e quickly and the properly but in the awake bring the cs f
0:02:23just the paillier of floating this finding restock implication that the weight bring has more
0:02:31resistance to the cs f influx
0:02:34so
0:02:36this leads to the thinking that probably the pats
0:02:40of the cs airflow is a smaller in the a weight bright surprisingly we found
0:02:47that
0:02:47the spaces between the two cells increase the around the
0:02:53sixty percent from awake state to the sleep state the radically the bigger space cost
0:03:00a more influx
0:03:01which were make the
0:03:02clear trends more efficiently
0:03:06so our study suggest that we need to sleep because we have a macroscopic leaning
0:03:11system that remove many of the toxic waste portal from the plane