0:00:03breast cancer consumers to remain the most common cancer diagnosed in women in the united
0:00:08states and is the same leading cause of cancer that in women
0:00:13the current lifetime risk of a woman developing breast cancer is one and eight or
0:00:17twelve point three percent
0:00:19several breast cancer risk factors have been identified over the years
0:00:24some of them up modifiable while others are not
0:00:27the objective of this review is just summarize the vector strategies directed at reducing the
0:00:33risk of breast cancer which are in thilo's an integrated approach in one thing identification
0:00:39of high risk women if a screening reference as well as nutritional pharmacological and surgical
0:00:45management
0:00:47so risk assessment tools the most common being together model
0:00:51clinicians determine the quantitative risk of breast cancer
0:00:55the role of selective oestrogen receptor modulator to marks the fan and scheme documented in
0:01:01change was established by several clinical trials
0:01:04such as the and f a b p one trial
0:01:07subsequently we lost if we also emerge as an option to emox of an with
0:01:12this reduction in the incidence of breast cancer reported in the star trial
0:01:18currently the united states to mark the fan
0:01:21and velocity are f t approved for this indication
0:01:25more recently a little bit ace inhibitors such as x m s t and announced
0:01:29result were shown to reduce the incidence of breast cancer in the map three and
0:01:34i was to trials respectively and may serve as an alternative to the selected oestrogen
0:01:40receptor modulator is what about to be favourable side effect profile
0:01:45the potential adverse effects of the schema preventive agents such as individual high publisher and
0:01:51trombone body disease with a marks the phone or a structure as hot flashes and
0:01:57all stripper roses with a limiting is inhibitors must be discussed with the patient before
0:02:02deciding on this approach
0:02:04it is estimated that over two million women in the united states could benefit from
0:02:08cuba prevention to reduce the risk of breast cancer however in reality it's uses rather
0:02:14limited possible explanations the disinclude
0:02:18difficulties identifying the ideal candidates for this approach
0:02:22decreased awareness amongst health care providers
0:02:25and high risk women and concerns about the potential adverse effects in the absence of
0:02:29the diagnosed cancer
0:02:31identifying the optimal candidate speaking about prevention strategies
0:02:35and it is to be challenging
0:02:37is the existing breast cancer risk assessment models do not incorporate or non risk factors
0:02:43for breast cancer and there is a significant variability in the overall design and points
0:02:48and inclusion criteria across clinical trials
0:02:52although there is no conclusive evidence to suggest the protective role of specific directory components
0:02:58alcohol consumption
0:02:59and obesity are associated with an increased breast cancer risk does lifestyle changes can you
0:03:05to a lower risk of developing breast cancer
0:03:09such approaches including bilateral risk reduction mastectomy
0:03:13and starting correctable
0:03:15i usually limited to agreement with the red terry predisposition to developing breast scan