and
stroke remains a common cause of morbidity and mortality within the general population
each year nearly eight hundred thousand new are required stroke events occur and account for
approximately one out of every eighteen das and united states
in addition to traditional cardiovascular risk factors and nontraditional factor that may contribute to stroke
risk is the use of non straight all in time phonatory drugs also known as
and sets
although much publicity has focused on the risk of adverse cardiac events
stroke compromises another important subset of risk
and this review we discuss the evidence with regard to an association between selective and
non selective and sets and stroke risk
potential mechanisms for an association are shown in table one these agents affect the balance
of various process acquaintance drum boxing process likely in the regulation of the cycle oxygen
e sands i'm with downstream effects shown in figure one
much of the initial suggestions of an association between and said in cardiovascular risk came
from perspective studies assessing easy agents into menstrual in cancer prevention
within these studies there was a suggestion of an association between and said and stroke
all the results were not consistent
much of the subsequent data demonstrating hind risk of stroke events
we're based on observational studies
and the relevant risk estimates from these studies are listed in table two
within these limited analyses observational studies have not found a different role risk with either
is schema or hammer abject stroke
elderly patients does or particular mention as chronic use of and sets increases with each
but then estimated up to forty percent of individuals over age sixty five years using
either over the counter are prescribed and sets
due to the increase risk adverse gastrointestinal and cardiovascular side effects
the use of and said in this population has been of ice to get
additionally hypotensive effects of and sets may be particularly prominent in the elderly
the current evidence does not support an association between and set used in stroke risk
in the elderly however and said you should be avoided whenever possible in favour of
non and said you know jeez
initial evidence from perspective trials demonstrating increase grist
of adverse how gregor basket or events
what to the withdrawal of several selective cox two inhibitors
although the evidence from these initial perspective trials suggest it is so she shouldn't with
coronary ski make advance
the evidence for a link between and said to instruct events remains a source of
debate
as the evidence here has been presented no definitive recommendations can be made regarding the
use of and sets with respect to stroke risk
however alternative energies it should be considered whenever possible particularly elderly and if and that's
are used there were duration should be a short as possible
future study should focus on further assessing the risk of specific vascular beds
such as the risk of stroke with specific and sets
but selective and on selective
thank you
and
they