| 0:00:05 | i don't wanna medical oncologist and can't a researcher in california |
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| 0:00:10 | for more than thirty years i've been involved in the development of cancer biological therapies |
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| 0:00:14 | and then you know therapies including monophone lana bodies limp the side there is in |
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| 0:00:20 | cancer vaccines |
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| 0:00:22 | that that's asked me to write a review covering melanoma vaccines because of the great |
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| 0:00:26 | interest in this approach |
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| 0:00:28 | a comprehensive review entitled melanoma vaccines trials and tribulations is now available in the online |
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| 0:00:35 | journal vaccine development and they're |
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| 0:00:39 | we know melanoma can respond only in there |
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| 0:00:42 | three you know if their products are already proved three melanoma and others are under |
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| 0:00:47 | development and the word about b |
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| 0:00:51 | this review covers many variables associated with melanoma vaccines including and events in coasting auditory |
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| 0:00:57 | agents |
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| 0:00:58 | sources of melanoma associated annotations |
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| 0:01:02 | and the results of clinical trials which are summarizes a series of tape |
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| 0:01:08 | maybe that things are given with coasting literary agents called at events |
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| 0:01:12 | the various classes allow difference to the been used as components of melanoma vaccines a |
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| 0:01:17 | review |
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| 0:01:18 | as well as clinical trials of melanoma vaccines that employ side fines including alpha and |
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| 0:01:23 | gamma interfere on |
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| 0:01:24 | in a look into and g m c s a |
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| 0:01:28 | recognition of the importance of dendritic cells granted and presentation |
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| 0:01:33 | as like to a number of trials testing and i melanoma dendritic sell products |
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| 0:01:37 | using peptides or tumour cells as sources advantage |
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| 0:01:42 | the many possible sources for melanoma associated and regions |
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| 0:01:46 | including specific molecules recognized by monica lana bodies and were side of toxic teal emphasized |
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| 0:01:53 | average in a tumour cell lines |
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| 0:01:55 | and not all of this tumour either is manipulations of whole tumour or in a |
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| 0:02:00 | psychologist tumour cell lines |
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| 0:02:03 | clinical trials using each of these approaches are tabulated as well as approaches involving injections |
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| 0:02:09 | directly in the tumour in vivo |
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| 0:02:11 | the identification and characterisation of melanoma to immerse themselves has focused attention on vaccines that |
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| 0:02:18 | may targets that's l |
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| 0:02:20 | a little randomised trials with halogen a cell lines of been disappointing |
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| 0:02:25 | at all this tumour cell line approaches are now feasible |
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| 0:02:29 | trials with such patients specific at a list to immerse themselves products |
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| 0:02:33 | especially when combined we didn't really excels in g m c s there |
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| 0:02:37 | are encouraging enough to justify confirmatory randomised trials and patience with metal static no |
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| 0:02:45 | the summary includes my opinions based on the current published evidence |
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| 0:02:49 | regarding and difference dendritic cells model of a one versus holiday one vaccines |
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| 0:02:55 | average and a result all the sources of and regions and whole ontologies tumour verses |
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| 0:03:00 | apologist tumour cell lines |
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| 0:03:02 | as an engine sources |
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| 0:03:04 | and help melanoma vaccines may enhance the benefit of monotone lana bodies the target image |
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| 0:03:09 | checkpoint molecules |
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| 0:03:12 | i think you'll find this an informative and comprehensive review thank you for your attention |
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