0:00:01my name is rubberness and i met him at holidays at the mayo clinic
0:00:05and it's my pleasure the present this video abstract
0:00:08and the manuscript written by rabbit emmanuel holly guy or and myself and voxal in
0:00:13the as an emerging therapy for model fibrosis
0:00:17model fibrosis is a chronic cologne all my lapel effort of ne of class
0:00:22it is a disease that affects individuals with wanna make early symptoms
0:00:27potential for site opinions
0:00:29the potential for progression look you'd milo talking and sadly frequently premature death from the
0:00:35onus
0:00:37in two thousand five it was of the discovery of achieve imitation in the model
0:00:41parallel for the veneer parzen half the genesis
0:00:44that of the jack to be six and seven f mutation
0:00:48the discovery that annotation lead to a rabbit effort to develop it is that were
0:00:53inhibitory of the jacks that pathway
0:00:56and hitters object one inject to have now been developed in tested in individuals with
0:01:02model fibrosis
0:01:03and the manuscript we discuss at least in development
0:01:08in early development eight in such as an s zero one eight o y two
0:01:12seventy four five four
0:01:14agents in face to face three testing set just as they are three o two
0:01:17five or three see what you three eight seven and procreate in
0:01:21these agents have demonstrated the ability
0:01:24for these inhibitors of jack to help to reduce plan a magazine these individuals and
0:01:30improve symptoms it is either maybe some variable benefits for anaemia related with the disease
0:01:36as demonstrated by c y t three eight seven and potentially poch written
0:01:41finally we going to the greatest detail in terms of the data for rock celine
0:01:46right solution of is now prove in the united states from the f d a
0:01:50as well as in europe in other countries
0:01:53based on the data from two randomized phase three trials
0:01:57these two trials called the comfort studies compared rocks a minute with either perceivable in
0:02:02the north american trial and versus best alternative therapy in the europeans trial
0:02:08these trials demonstrated that compared to these control on the rocks and then the
0:02:11was significantly superior for the reduction of smell mightily
0:02:15improving symptoms related with the disease improving quality of life
0:02:19and now improvement in survival compared to those control are
0:02:24in the manuscript we going to a discussion of the use approximate and then we
0:02:28talk about upcoming combination clinical trials
0:02:31as well as new drugs in development
0:02:33we also try to portray the futures keep up there before model fibrosis
0:02:38thanks to all of these scientific energy but into the disease particle e over these
0:02:42last five years is a much brighter future for patients with modified process
0:02:48thank