well
my name is jennifer occur in geneva
and i met coauthor of the manuscript entitled pell appeared on comedy versus your spare
down long acting intractable
and subjects with schizophrenia
recently treated with oral we're spare down
or other or lms the context
schizophrenia i faxed just over one percent of the adult population with an estimated fifty
one million suffer worldwide
all those symptoms can be treated of actively with in a psychotic medication
for adherence to prescribe treatment is a well recognise problem
for adherence is associated with clinical
and functional deterioration
an increased risk a relapse
we have scroll addition and suicidal behaviour
simplified and i psychotic medication regimens
such as long acting intractable formulations
may be helpful
in improving adherence
patients given oral once daily dosing must remember to take their medication three hundred and
sixty five times a year
with a long acting intractable formulation
this is reduced to twenty six times yearly for biweekly dosing and twelve times yearly
for monthly dosing
also with marketing intractable and as the context
health care providers can be certain of their patient's adherence and resources are not wasted
on discarded or forgotten medication
it is unclear whether certain subpopulations within the schizophrenia spectrum
would be likely to benefit from these potential advantages
in particular because of the similarity between the molecules
one might question whether person to have failed treatment with or were spared own
we show a good quote corresponds to long acting pell occurred on comedy
or long acting wrist area down
and this article we describe a post hoc subgroup analysis of a thirteen week randomised
double one trial
undertaken to address this question
the original trial evaluated response to treatment with long acting intractable help her don't comedy
or long acting inject upon which their down
in subjects with schizophrenia who were experiencing clinically significant symptoms
despite recent treatment with oral pinnits the context
efficacy was measured by noting improvements in pans total score
p and factor scores
and c g i severity scale score a total of seven hundred and forty seven
subjects from the original study were included in this subgroup analysis
during the two weeks before the start of the double blind study medication two hundred
and thirty three subjects had received or over spare don't
four hundred and two had received another oral in a psychotic
and one hundred and twelve had not received any in a psychotic medication
at the end of thirteen weeks of treatment
statistically significant improvements from baseline and point
where seen in all f sixty measures
within each group for both pell appeared on comedy
under stared on long acting injection
regardless of previous oral in a psychotic treatment
you can see from the highlighted data
that a change from base fine for all parameters appeared similar across groups
their responses were statistically significant
all comparisons within each group had a p-value less than or equal to zero point
zero two
similarly
functioning improved significantly for subjects within each group
for about how they are not comedy and they were spared on long acting injection
personal and social performance scale
or psp
scores significantly improved from baselines and point among all previous treatment subgroups
this speaker shows that the distribution of categorical p s p scale scores
improved across all groups from baselines and point
from two to sixty one percent of subjects across the subgroups analyzed experience one or
more treatment immersion adverse of that
common adverse events or power pair don't comedy it subjects
where insomnia
seven point one to twelve point six percent
had a week six point three to nine percent
an injection site pain
three to ten point seven percent
you respective of higher order we're stared on status
common adverse events for all over spared on long acting injections subjects were insomnia
five point sixty eight point four percent and headache
five point forty nine point four percent
in summary
our analysis suggests that treatment with how appeared on comedy or were spared on long
acting injection can be effective in patients
regardless of previous oral in a psychotic treatment
for patients who had previously received or over spare don't only
the difference in the formulation was the mean change in the intervention
as the molecules oliver remain the same or similar
these data support the contribution
of a long acting formulation
to improving treatment response
and suggest that not adherence may be a significant contributor to in an adequate efficacy
oral formulations impatience with schizophrenia
thank you for your interest
and we hope you have found our analysis useful
in the management of you are patients who are receiving in a psychotic each utterance