| 0:00:01 | i'm still as a result from the university of north carolina chapel hill |
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| 0:00:05 | and the last few years there's been accumulating evidence that colin is really important for |
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| 0:00:11 | female development |
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| 0:00:13 | and that pregnant women may not be getting enough colleen and die |
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| 0:00:18 | calling this a new tree that is only recently recognised as being required by humans |
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| 0:00:25 | and |
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| 0:00:26 | you people are not pregnant develop fatty liver labour damage muscle damage when the pride |
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| 0:00:31 | that |
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| 0:00:33 | but there are many things that ali us to believe that colin is really important |
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| 0:00:38 | during pregnancy for example |
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| 0:00:41 | pregnant women transport coupling to the baby against a concentration gradient across the placenta and |
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| 0:00:48 | they can accumulate fifteen times more correlated to the baby then that's present in their |
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| 0:00:53 | blood |
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| 0:00:54 | pregnant women secrete colleen in their milk and milk you milk is one of the |
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| 0:00:59 | richest sources of cali available |
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| 0:01:04 | in addition |
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| 0:01:06 | the reason that we didn't know that colin was required for you images is that |
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| 0:01:10 | we thought that labour |
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| 0:01:13 | possesses a pathway enzyme that can make only from scratch |
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| 0:01:18 | it turns out that this enzyme is turned on by oestrogen and then men and |
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| 0:01:22 | post menopausal women is not very |
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| 0:01:25 | but in women especially at the oestrogen concentrations they reach during pregnancy |
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| 0:01:31 | make skulking to help supplement the dietary intake make it less likely that they will |
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| 0:01:37 | become to finish |
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| 0:01:38 | so why worry the women might be equally well we found that about forty four |
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| 0:01:44 | percent of women in the us have a genetic |
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| 0:01:49 | polymorphism a misspelling of the genetic that results in the inability to turn on the |
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| 0:01:55 | street or that's trick and those women have a special requirement for calling increase dietary |
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| 0:02:02 | requirements colin probably during pregnancy run into trouble if we take animal models wraps |
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| 0:02:08 | and mice and feed them locally during pregnancy their babies are born |
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| 0:02:15 | decreased a capital function decrease neural genesis and okay this and we give them extra |
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| 0:02:20 | cuddly they have increase your a genesis and happy campers increased memory function for the |
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| 0:02:25 | rest of their lives and that affect seems to be mediated by a genetic mac |
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