0:00:00however
0:00:01i'm stepping injuries
0:00:03and like to tell you briefly about the paper read a whole than i have
0:00:07written
0:00:09characteristics in management of a new related adverse impacts associated with it will now and
0:00:14you in their be formatted static melanoma
0:00:18just a little background
0:00:20when diagnosed in the early stages melanoma is highly treatable and associated with good long-term
0:00:25l
0:00:27however for patients diagnosed with it being instrument a static melanoma
0:00:31the prognosis is much or
0:00:34and you in you know therapeutic agent it a little map has been approved for
0:00:38the treatment of a payments are made a static melanoma
0:00:42it is been shown to significantly improve overall survival intonation
0:00:46but it will in the map can also cause i mean related adverse to
0:00:51or only or a e
0:00:53and are unlikely tight if you little amount of meaning related mechanism of action
0:00:58are paper discusses the most common i already and how to manage the of the
0:01:03so that patients can stay on their t and hopefully have a successful outcome
0:01:09when the map is in the start as a ninety minute intravenous infusions and a
0:01:14dose of three milligrams per kilogram every three weeks for four doses over a period
0:01:18of twelve week
0:01:20the most common i are eighties include toxicity is that this again gastrointestinal tract
0:01:26integrated system in liver
0:01:28let's come and higher rate easing clean neurological ocular
0:01:32overall the original and prompt intervention and the use of cortical steroids have been successful
0:01:38in clinical trials to manage higher at
0:01:41timed onset of i r a you can be re
0:01:44but most occur within the first well we face actually
0:01:48however some can be seen as early as following the first rate
0:01:52especially in the case of dermatological
0:01:55others can occur for weeks or even not activation completed their p
0:02:00especially as seen in the case of integrated
0:02:04you're great events occur in lemma map may need to be withheld or even remotely
0:02:09discontinue
0:02:10but in many cases i already is can be successfully managed impatient can continue air
0:02:16e
0:02:17in our paper we were you for cases to illustrate the management for the most
0:02:21common types that i are at the intonation
0:02:25these are immune related german titus
0:02:28intra collided hepatitis endangered or not
0:02:32i had a spatial the stage for melanoma accuracy three times as the baby limit
0:02:36mapping presented with them terms of severe fifty headache in cognitive dysfunction
0:02:42even though brehm a task this is the first consideration a prophesy they should also
0:02:47be considered as anyone that is received little now
0:02:51and the brain would be to terry should be order to assess for pituitary swelling
0:02:57as well as lab worked with that's pituitary gland
0:03:01this case is one of four percent in our paper along with more detailed information
0:03:05on the specific the management of that type of i r a e
0:03:10to conclude it really matters than a whole f t i approved in you know
0:03:14they're a chipper and respectable and then a static melanoma
0:03:18due to its characteristic distinctive mechanism of action
0:03:22it being the map elicit a number of specific i alright he's
0:03:26expedient in careful recognition monitoring of i are eighties that may occur during treatment would
0:03:31it be little about
0:03:33male how patients to continue to benefit from their p
0:03:36and optimize
0:03:39i hope you find this helpful
0:03:41thank you for listening