however
i'm stepping injuries
and like to tell you briefly about the paper read a whole than i have
written
characteristics in management of a new related adverse impacts associated with it will now and
you in their be formatted static melanoma
just a little background
when diagnosed in the early stages melanoma is highly treatable and associated with good long-term
l
however for patients diagnosed with it being instrument a static melanoma
the prognosis is much or
and you in you know therapeutic agent it a little map has been approved for
the treatment of a payments are made a static melanoma
it is been shown to significantly improve overall survival intonation
but it will in the map can also cause i mean related adverse to
or only or a e
and are unlikely tight if you little amount of meaning related mechanism of action
are paper discusses the most common i already and how to manage the of the
so that patients can stay on their t and hopefully have a successful outcome
when the map is in the start as a ninety minute intravenous infusions and a
dose of three milligrams per kilogram every three weeks for four doses over a period
of twelve week
the most common i are eighties include toxicity is that this again gastrointestinal tract
integrated system in liver
let's come and higher rate easing clean neurological ocular
overall the original and prompt intervention and the use of cortical steroids have been successful
in clinical trials to manage higher at
timed onset of i r a you can be re
but most occur within the first well we face actually
however some can be seen as early as following the first rate
especially in the case of dermatological
others can occur for weeks or even not activation completed their p
especially as seen in the case of integrated
you're great events occur in lemma map may need to be withheld or even remotely
discontinue
but in many cases i already is can be successfully managed impatient can continue air
e
in our paper we were you for cases to illustrate the management for the most
common types that i are at the intonation
these are immune related german titus
intra collided hepatitis endangered or not
i had a spatial the stage for melanoma accuracy three times as the baby limit
mapping presented with them terms of severe fifty headache in cognitive dysfunction
even though brehm a task this is the first consideration a prophesy they should also
be considered as anyone that is received little now
and the brain would be to terry should be order to assess for pituitary swelling
as well as lab worked with that's pituitary gland
this case is one of four percent in our paper along with more detailed information
on the specific the management of that type of i r a e
to conclude it really matters than a whole f t i approved in you know
they're a chipper and respectable and then a static melanoma
due to its characteristic distinctive mechanism of action
it being the map elicit a number of specific i alright he's
expedient in careful recognition monitoring of i are eighties that may occur during treatment would
it be little about
male how patients to continue to benefit from their p
and optimize
i hope you find this helpful
thank you for listening