0:00:00hello my name is jennifer courage leave a and i one of the co authors
0:00:04of the manuscript entitled long-term tyler ability of once monthly intractable how apparent on comedy
0:00:11and subjects with recently diagnosed schizophrenia
0:00:16ambitions for schizophrenia the first five to ten years of illness
0:00:21is a critical period for f active intervention
0:00:24to prevent deterioration optimize outcomes
0:00:28however patients are often on adherence with their entire psychotic medication
0:00:35the use of long acting intractable in a psychotic agents may be inappropriate option for
0:00:40these patients
0:00:41well i think intractable agents removed think need to remember to take the only medication
0:00:47and their long half lives provide a wide window for missed doses before plasma levels
0:00:53becomes sub therapeutic
0:00:56however the use of these agents may pose taller ability concerns for clinicians impatience
0:01:03well patience early in their illness are often responsive to in a psychotic treatment
0:01:08they may be sensitive to adverse the fax
0:01:11such as extra parental symptoms we king grill action related to fax and situation
0:01:18in this manuscript my co investigators and i examine this issue in a post hoc
0:01:23analysis of an international trial of the long acting intractable and a psychotic
0:01:29however paired on comedy
0:01:31in this study six hundred and forty five subjects received continuous treatment with power paired
0:01:37on comedy
0:01:38in this flowchart
0:01:39we see that two hundred and sixteen were categorized as having a recently diagnosed schizophrenia
0:01:45meaning that their diagnosis was within the last five years
0:01:49four hundred and twenty nine had a longer duration of diagnosis and the referred to
0:01:54as the chronic illness subgroup
0:01:57in both groups the mean monthly dose was a hundred and nine milligrams
0:02:02and the continuous mean exposure to tell appeared on comedy was three hundred and thirty
0:02:07four days and the recently diagnosed and three hundred and nine days in the chronic
0:02:12illness group we examined all reported adverse events as well as the measures of extra
0:02:18criminal sometimes glucose
0:02:20pro locked in and body weight in the two subgroups
0:02:23first we examined the percentages of subjects in each subgroup reported any adverse event
0:02:30from the time of the first injection to the completion that specific time points
0:02:36and found that during the month following the first injection
0:02:39thirty one point five percent of recently diagnosed and forty two point seven percent of
0:02:45those in the chronic illness subgroup reported in adverse to that in general the instance
0:02:50rate at these intervals suggested that adverse events
0:02:54were less likely in the recently diagnosed some group and in the chronically ill subgroup
0:03:00in our assessment of individual adverse events
0:03:03those occurring at a two percent or greater margin between their recently diagnosed and chronic
0:03:09illness sub groups were identified
0:03:12we then determine the relative risks and ninety five percent confidence intervals for these events
0:03:19events considered potentially significant between groups
0:03:23where those in which the ninety five percent confidence interval
0:03:26did not include one
0:03:29using these criteria nasal fair and right is what's a potentially significant event
0:03:34reported in were chronically ill
0:03:36then recently diagnosed subjects
0:03:38i one six nine twelve and point
0:03:43influenza and a manner we have we're potentially significant and that's reported in more recently
0:03:48diagnosed then chronically ill subjects and point
0:03:52this figure illustrates these data at the overall study and points with the exception of
0:03:58meat so there and right is that occurred in more chronically ill then recently diagnosed
0:04:03subjects
0:04:04and influenza and in mandarin that occurred in more recently diagnosed and chronically ill subjects
0:04:11there were no other events considered potentially significant between the sub groups
0:04:17we then examined rates if any extra parameter symptom events and found the used to
0:04:23be numerically lower in the recently diagnosed subgroup at each time period
0:04:28with these ranging from two point three percent to nine point three percent in the
0:04:33recently diagnosed subgroup and from five point eight percent just twelve point six percent and
0:04:39the chronically ill subgroup
0:04:41in evaluation of specific individual actual parameter all symptom related prefer terms
0:04:49we found as summarised in this next table that to occur at e two percent
0:04:54or greater margin between groups
0:04:57among the specific preferred terms
0:04:59not specific extra parameter disorder
0:05:02as reported right more recently diagnosed subjects and i feature which reported by more chronically
0:05:09ill subjects
0:05:11we changes and glucose related measures appeared similar between the sub groups
0:05:17in our assessment of changes from baseline in perl acton levels
0:05:21we found i summarised in this table that there were increases in both sexes in
0:05:27both subgroups
0:05:29reader increases observed in females than and males and each subgroup also reluctant levels were
0:05:36higher in females with early illness compared females with more chronic illness in analysis of
0:05:42potentially prolonged and related events
0:05:45we found a summarised in this next table
0:05:48that the rates of pearl action related events was seven point nine percent and those
0:05:53with a more recent diagnosis
0:05:55and three point five percent in those with more chronic illness
0:05:59to summarize we found in this post hoc analysis of a multi face study that
0:06:05the long term taller ability of pell appear don't comedy was generally similar in recently
0:06:11diagnosed schizophrenia subjects
0:06:13and in those with more chronic illness
0:06:16with the exception of temporal action related measures
0:06:19we hope that these findings will be useful to help guide clinicians and the management
0:06:24of patients
0:06:25early in the course of their illness