hello my name is jennifer courage leave a and i one of the co authors

of the manuscript entitled long-term tyler ability of once monthly intractable how apparent on comedy

and subjects with recently diagnosed schizophrenia

ambitions for schizophrenia the first five to ten years of illness

is a critical period for f active intervention

to prevent deterioration optimize outcomes

however patients are often on adherence with their entire psychotic medication

the use of long acting intractable in a psychotic agents may be inappropriate option for

these patients

well i think intractable agents removed think need to remember to take the only medication

and their long half lives provide a wide window for missed doses before plasma levels

becomes sub therapeutic

however the use of these agents may pose taller ability concerns for clinicians impatience

well patience early in their illness are often responsive to in a psychotic treatment

they may be sensitive to adverse the fax

such as extra parental symptoms we king grill action related to fax and situation

in this manuscript my co investigators and i examine this issue in a post hoc

analysis of an international trial of the long acting intractable and a psychotic

however paired on comedy

in this study six hundred and forty five subjects received continuous treatment with power paired

on comedy

in this flowchart

we see that two hundred and sixteen were categorized as having a recently diagnosed schizophrenia

meaning that their diagnosis was within the last five years

four hundred and twenty nine had a longer duration of diagnosis and the referred to

as the chronic illness subgroup

in both groups the mean monthly dose was a hundred and nine milligrams

and the continuous mean exposure to tell appeared on comedy was three hundred and thirty

four days and the recently diagnosed and three hundred and nine days in the chronic

illness group we examined all reported adverse events as well as the measures of extra

criminal sometimes glucose

pro locked in and body weight in the two subgroups

first we examined the percentages of subjects in each subgroup reported any adverse event

from the time of the first injection to the completion that specific time points

and found that during the month following the first injection

thirty one point five percent of recently diagnosed and forty two point seven percent of

those in the chronic illness subgroup reported in adverse to that in general the instance

rate at these intervals suggested that adverse events

were less likely in the recently diagnosed some group and in the chronically ill subgroup

in our assessment of individual adverse events

those occurring at a two percent or greater margin between their recently diagnosed and chronic

illness sub groups were identified

we then determine the relative risks and ninety five percent confidence intervals for these events

events considered potentially significant between groups

where those in which the ninety five percent confidence interval

did not include one

using these criteria nasal fair and right is what's a potentially significant event

reported in were chronically ill

then recently diagnosed subjects

i one six nine twelve and point

influenza and a manner we have we're potentially significant and that's reported in more recently

diagnosed then chronically ill subjects and point

this figure illustrates these data at the overall study and points with the exception of

meat so there and right is that occurred in more chronically ill then recently diagnosed

subjects

and influenza and in mandarin that occurred in more recently diagnosed and chronically ill subjects

there were no other events considered potentially significant between the sub groups

we then examined rates if any extra parameter symptom events and found the used to

be numerically lower in the recently diagnosed subgroup at each time period

with these ranging from two point three percent to nine point three percent in the

recently diagnosed subgroup and from five point eight percent just twelve point six percent and

the chronically ill subgroup

in evaluation of specific individual actual parameter all symptom related prefer terms

we found as summarised in this next table that to occur at e two percent

or greater margin between groups

among the specific preferred terms

not specific extra parameter disorder

as reported right more recently diagnosed subjects and i feature which reported by more chronically

ill subjects

we changes and glucose related measures appeared similar between the sub groups

in our assessment of changes from baseline in perl acton levels

we found i summarised in this table that there were increases in both sexes in

both subgroups

reader increases observed in females than and males and each subgroup also reluctant levels were

higher in females with early illness compared females with more chronic illness in analysis of

potentially prolonged and related events

we found a summarised in this next table

that the rates of pearl action related events was seven point nine percent and those

with a more recent diagnosis

and three point five percent in those with more chronic illness

to summarize we found in this post hoc analysis of a multi face study that

the long term taller ability of pell appear don't comedy was generally similar in recently

diagnosed schizophrenia subjects

and in those with more chronic illness

with the exception of temporal action related measures

we hope that these findings will be useful to help guide clinicians and the management

of patients

early in the course of their illness