my name is rubberness and i met him at holidays at the mayo clinic

and it's my pleasure the present this video abstract

and the manuscript written by rabbit emmanuel holly guy or and myself and voxal in

the as an emerging therapy for model fibrosis

model fibrosis is a chronic cologne all my lapel effort of ne of class

it is a disease that affects individuals with wanna make early symptoms

potential for site opinions

the potential for progression look you'd milo talking and sadly frequently premature death from the

onus

in two thousand five it was of the discovery of achieve imitation in the model

parallel for the veneer parzen half the genesis

that of the jack to be six and seven f mutation

the discovery that annotation lead to a rabbit effort to develop it is that were

inhibitory of the jacks that pathway

and hitters object one inject to have now been developed in tested in individuals with

model fibrosis

and the manuscript we discuss at least in development

in early development eight in such as an s zero one eight o y two

seventy four five four

agents in face to face three testing set just as they are three o two

five or three see what you three eight seven and procreate in

these agents have demonstrated the ability

for these inhibitors of jack to help to reduce plan a magazine these individuals and

improve symptoms it is either maybe some variable benefits for anaemia related with the disease

as demonstrated by c y t three eight seven and potentially poch written

finally we going to the greatest detail in terms of the data for rock celine

right solution of is now prove in the united states from the f d a

as well as in europe in other countries

based on the data from two randomized phase three trials

these two trials called the comfort studies compared rocks a minute with either perceivable in

the north american trial and versus best alternative therapy in the europeans trial

these trials demonstrated that compared to these control on the rocks and then the

was significantly superior for the reduction of smell mightily

improving symptoms related with the disease improving quality of life

and now improvement in survival compared to those control are

in the manuscript we going to a discussion of the use approximate and then we

talk about upcoming combination clinical trials

as well as new drugs in development

we also try to portray the futures keep up there before model fibrosis

thanks to all of these scientific energy but into the disease particle e over these

last five years is a much brighter future for patients with modified process

thank