a little time you one was a professor in the department of only clear madison
at a long university and i'm bleeding a genomic research program on cards you respiratory
disease a decent to invest that like of the energy than what is you get
back
and the author audible books publications and title updates on this u p teaching this
pollution international journal of c p d
i was first asked to review the genetics of c u p d in two
thousand and eight which later publications in two thousand and nine in the journal far
mccall june it makes
since that publications i'm keeping track of the literatures as a major research interests
there's a key features that i would like to highlight in this review article
first are table one and supplementary table one
these tables provide summarize genetic association studies in ensue p d and related and a
type
publish before two thousand and eleven
there's a total of one hundred and ninety two genes in and this table and
the goal of this table was to provide a comprehensive list of publications for any
giving genes without judging the quality of these publications
so in figure one
i am illustrate all these one hundred and ninety two genes in one if you
so if you look at figure one on the x axis you can see the
number of studies supporting the associations
and on the y-axis the number of genes
and for example if you look at the second bar you can see that at
sixteen genes where supported by at least one of publications
and their need that bar you can see the eighty six genes
you can also see in this figure that there are seven genes that were replicate
in more than ten publications
however these are not necessarily the most robust genes associated with superior or related find
it i
in fact if you will in figure number two you can see the relationship between
the positive and negative studies
as an example if you look at the upper right corner of this figure you
can see that teen of chains we can found in the literatures twenty publication that
support the genetic variance and eighteen of genes are associated with a with soupy you
are related to find a type however we can also find twenty
different publications that do not support such association
so it seems that genes that are the most replicate ensue p d are simply
the genes that are the most popular genes that
and perhaps the most convincing soupy d jeans so far are those that are less
study but consistently replicated as illustrate and the lower right corner of that figure
i think the most important discoveries in the field of genetics of superiors ring the
past few years where the right from june on why association studies
in the text i describe each of the g was published in c p d
and long functions and related complications all the major findings are summarised in table two
finally i completely article by giving some of my perspectives in the field
i thing identifying them only clear basis of c p d is challenging
but i think the years ahead are likely to be very exciting
janet i think geneticist will need to work together a but also with t the
full spectrum of experts that are treating patients with soupy d in order to have
large sample size as well as to have fun to types that are very well
characterize with precise penetrate
i also think that we need more than g was studies
we need more integrative genomics approach and i briefly touch on about this side jamaican
research projects that i'm doing with my colleagues on long specimens are identified long qta
else
so i hope that this collection of studies will be a useful for researchers in
the field and it can also provide concise overview for of the genetics of soupy
d for the general readers of the international journal of soupy
thanks for listening and i hope you enjoy reading it